结论神经生长因子治疗脑性瘫痪有较明显的疗效且应用简单无毒副作用
【关键词」神经生长因子;脑性瘫痪;康复
[中图分类号」8742.3[文献标识码」A[文章编号]1671-8925(2005)04-383-004
}
Therapeutic effect of nerve growth factor injection on child cerebral palsy in the
multicenter
treatment YAN Chao-ying*, MA Bin-xiang SHA、‘认ng.刀I N Hui-lin, ZHA、‘口ing-
song.
*Department of Pediatrics, First找户lirded Hospital of Jilin University, Changchun
130061, China
[Abstract」 O川ective To investigate the therapeutic effect of nerve growth
factor injection on the
treatment of child cerebral palsy (CP). Methods 132 cases (observation group) and
95 cases (control
group) of CP were treated by rehabilitation therapy, but in the observation group,
nerve growth factor was
added through muscle injection for 4 periods. The therapeutic effect in the 2
groups was compared on the
basis of standard diagnostic criteria for CP in 5 hospitals of China. Results The
therapeutic effect in
observation group (87.1%) was more satisfactory than in control group (76.8%),
there being the significant
difference (P<0.01). The effective rate was higher in the children of fewer than 3
years old. Conclusion
Application of nerve growth factor can benefit obviously the treatment of CP with
advantages of simply
operation and no side effects
[Key words」 Nerve growth factor; Cerebral palsy; Rehabilitation
小儿脑性瘫痪是小儿时期常见的一种严重致残性疾病,它直接影响到我国人口素质。鼠神
四、脑干听觉诱发电位改善情况
表2脑瘫疗效评定结果
Tab.2 Evaluation of therapeutic effect
Efficiency rate
塑洲圳叫圳
Curative effect
Observation group (0-3 years old)
Control (> 3 years old)
Observation group (0-3 years old)
Control (> 3 years old)
Notable efficacy
::
:{
56(58.3%)
15(41.7%)
26(42.6%)
11(32.4%)
Effic
31(32
13(36
22(36
13(38
Inefficacy
9(9.4%)
8(22.2%)
13(21.4%)
10(29.4%)
90.6%
77.8%
78.6%
70‘%
表3 0-3岁儿童治疗后CDCC测查结果的比较(油)
Tab.3 Comparison of CDCC test results in the children of fewer than 3 years
old(x}s)
MDI PDI
Group n——
}
Control
NGFtreatment
::
64110.12
66+9.54
72112.09
71+15 34
-F<0.01 v, pre-treatment; 0P< 0.01 vs control group
表4大于3岁儿童智力发育改善韦氏量表(x})
Tab.4 Wechsler test of the children of more than 3 years old你mss)
Group
Control
NGF treatment
Pre-treatment IQ
Post-treatment IQ
3436
76.43110.12
7732+962
80.97115.54*
凡924+13凡2"0
*s=2.25, P<0.05 v, pre-treatment; "".62, P<0.01 vs pre-treatment; 0e=7.38,P<0.01
v, control group
after treatement
对照组28例异常,治疗后9例正常,7例好转,12例无变化;治疗组34例异常,治疗后12例正